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Dekanty Lab

@ Instituto de Agrobiotecnologia del Litoral 

UNL - CONICET

 

Our Work

In our lab we are interested in understanding the regulation of growth, tissue and metabolic homeostasis in vivo using mainly Drosophila melanogaster as a model organism.

 
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Adipose p53 function in nutrient sensing and metabolic homeostasis

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Publications

Summary

2020 Oct 27

Cell Reports

Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy Under Nutrient Stress via Drosophila Upd2 Repression. Ingaramo MC, Sanchez JA, Perrimon N, Dekanty A 
doi: 10.2139/ssrn.3636383.

2019 Aug 19

PLoS Genetics

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila. Sanchez JA, Mesquita D, Ingaramo MC, Ariel F, Milán M, Dekanty A 
doi: 10.1371/journal.pgen.1008133.

2018 May 23

Mechanisms of Development

Regulation and function of p53: A perspective from Drosophila studies. Ingaramo MC, Sanchez JA, Dekanty A
doi: 10.1016/j.mod.2018.05.007.

2014 Jul 24

Cell Reports

MicroRNA-mediated regulation of Dp53 in the Drosophila fat body contributes to metabolic adaptation to nutrient deprivation. Barrio L, Dekanty A, Milán M.
doi: 10.1016/j.celrep.2014.06.020

2015 Feb 19

Oncogene

Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells. Dekanty A, Barrio L, Milán M.
doi: 10.1038/onc.2014.42.

2012 Dec 11

PNAS

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. Dekanty A, Barrio L, Muzzopappa M, Auer H, Milán M.
doi: 10.1073/pnas.1206675109.

2013 Mar 1

Cell Cycle

Aneuploidy, cell delamination and tumorigenesis in Drosophila epithelia. Dekanty A, Milán M.
doi: 10.4161/cc.23949.

2010 Dec 14

PLoS Biology

A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. Mesquita D, Dekanty A, Milán M.
doi: 10.1371/journal.pbio.1000566.

 

Members

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Andres Dekanty
(flipping flies during lockdown;)

Principal Investigator

Andres Dekanty obtained his PhD in 2008 from the Instituto Leloir/Universidad de Buenos Aires (UBA, Argentina). In 2008, he joined the laboratory of Marco Milan as a postdoc at the Institute for Research in Biomedicine (IRB Barcelona, Spain). Since 2014, he is a member of CONICET and Professor at the Universidad Nacional del Litoral (UNL, Argentina).

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Maria Clara Ingaramo

PhD Student

I received my Bachelor's degree in Biotechology from Universidad Nacional del Litoral, in Argentina. After some years of following a carrer in business I came back to science. At Dekanty Lab, I am interested on the role of p53 in metabolism, particularly in response to nutrient stress.

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Juan Sanchez

PhD Student

I obtained my degree in Biotechnology from Universidad Nacional del Litoral. As a PhD student in Dekanty's Lab, I use the Drosophila wing as a model to study coordinated tissue gowth. 

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María Paula Gervé

PhD Student

I am studying the role of the conserved transcription factor Myc in regulating the biogenesis of miRNAs and the levels of p53 in Drosophila.

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Alejandro Zapata

Undergraduate Student

I am pursuing a degree in Biotechnology at the Universidad Nacional del Litoral, in Argentina. In the lab I am starting a new project related to aging and also do technical support.

 

Contact Us

Colectora Ruta Nac. Nº168 km. 0
Paraje el Pozo s/n 3000 - Santa Fe

+54 342 4511370 ext. 5022

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