Dekanty Lab
@ Instituto de Agrobiotecnologia del Litoral
UNL - CONICET
Our Work
In our lab we are interested in understanding the regulation of growth, tissue and metabolic homeostasis in vivo using mainly Drosophila melanogaster as a model organism.
Adipose p53 function in nutrient sensing and metabolic homeostasis
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Publications
Summary
2020 Oct 27
Cell Reports
Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy Under Nutrient Stress via Drosophila Upd2 Repression. Ingaramo MC, Sanchez JA, Perrimon N, Dekanty AÂ
doi: 10.2139/ssrn.3636383.
2019 Aug 19
PLoS Genetics
Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila. Sanchez JA, Mesquita D, Ingaramo MC, Ariel F, Milán M, Dekanty AÂ
doi: 10.1371/journal.pgen.1008133.
2018 May 23
Mechanisms of Development
Regulation and function of p53: A perspective from Drosophila studies. Ingaramo MC, Sanchez JA, Dekanty A
doi:Â 10.1016/j.mod.2018.05.007.
2014Â Jul 24
Cell Reports
MicroRNA-mediated regulation of Dp53 in the Drosophila fat body contributes to metabolic adaptation to nutrient deprivation. Barrio L, Dekanty A, Milán M.
doi: 10.1016/j.celrep.2014.06.020
2015 Feb 19
Oncogene
Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells. Dekanty A, Barrio L, Milán M.
doi: 10.1038/onc.2014.42.
2012 Dec 11
PNAS
Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. Dekanty A, Barrio L, Muzzopappa M, Auer H, Milán M.
doi: 10.1073/pnas.1206675109.
2013 Mar 1
Cell Cycle
Aneuploidy, cell delamination and tumorigenesis in Drosophila epithelia. Dekanty A, Milán M.
doi: 10.4161/cc.23949.
2010 Dec 14
PLoS Biology
A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. Mesquita D, Dekanty A, Milán M.
doi: 10.1371/journal.pbio.1000566.
Members
Andres Dekanty
(flipping flies during lockdown;)
Principal Investigator
Andres Dekanty obtained his PhD in 2008 from the Instituto Leloir/Universidad de Buenos Aires (UBA, Argentina). In 2008, he joined the laboratory of Marco Milan as a postdoc at the Institute for Research in Biomedicine (IRB Barcelona, Spain). Since 2014, he is a member of CONICET and Professor at the Universidad Nacional del Litoral (UNL, Argentina).
Maria Clara Ingaramo
PhD Student
I received my Bachelor's degree in Biotechology from Universidad Nacional del Litoral, in Argentina. After some years of following a carrer in business I came back to science. At Dekanty Lab, I am interested on the role of p53 in metabolism, particularly in response to nutrient stress.
Juan Sanchez
PhD Student
I obtained my degree in Biotechnology from Universidad Nacional del Litoral. As a PhD student in Dekanty's Lab, I use the Drosophila wing as a model to study coordinated tissue gowth.
MarÃa Paula Gervé
PhD Student
I am studying the role of the conserved transcription factor Myc in regulating the biogenesis of miRNAs and the levels of p53 in Drosophila.
Alejandro Zapata
Undergraduate Student
I am pursuing a degree in Biotechnology at the Universidad Nacional del Litoral, in Argentina. In the lab I am starting a new project related to aging and also do technical support.
Contact Us
Colectora Ruta Nac. Nº168 km. 0
Paraje el Pozo s/n 3000 - Santa Fe
+54 342 4511370 ext. 5022
